Post-Conditioning for Cardioprotection During Reperfusion Therapy
نویسندگان
چکیده
منابع مشابه
Injection of isolated mitochondria during early reperfusion for cardioprotection.
Previously, we demonstrated that ischemia induces mitochondrial damage and dysfunction that persist throughout reperfusion and impact negatively on postischemic functional recovery and cellular viability. We hypothesized that viable respiration-competent mitochondria, isolated from tissue unaffected by ischemia and then injected into the ischemic zone just before reperfusion, would enhance post...
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The mitochondrion has evolved as an important organelle in determining cell survival and cell death. It is involved in a plethora of processes in mammalian cells including ATP production, steroid synthesis, and cell division and cell death. Indeed, mitochondrial dysfunction is associated with numerous human maladies including heart disease. Mitochondrial diseases have traditionally been attribu...
متن کاملPost-conditioning through lower limb ischemia-reperfusion can alleviate lung ischemia-reperfusion injury.
OBJECTIVE Operation on the infrarenal aorta could cause ischemic-reperfusion (IR) injury in local tissues and remote organs (e.g. the lung). We aim to explore the method of reducing lung ischemia-reperfusion damage after lower limb IR with post conditioning (LIPC). METHODS Bilateral lower limb ischemia was performed in Sprague-Dawley (SD) rats, and then animals were divided into 4 groups: IR-...
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Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes o...
متن کاملSpotlight on cardioprotection against ischemia-reperfusion injury.
Worldwide, coronary heart disease (CHD) causes approximately one-third of all deaths in men and one-quarter of all deaths in women and represents a significant threat to public health. The global burden of CHD in terms of disability-adjusted life years (DALY) or " healthy years of life lost " is projected to increase from around 47 million DALY globally in 1990 to 82 million in 2020 [1]. Myocar...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2010
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2009.11.002